A.G.E.s impact the whole body but it is particularly important for those who suffer from a chronic disease to learn how they are impacting you.
A.G.E.s are found at high levels in the brains of people suffering from Alzheimer's, Huntington's and Parkinson's disease where they are thought to increase neuronal degeneration (1).
High A.G.E. levels in the eye is thought to change the structure and integrity of proteins within the cornea, retina, lens and optic nerves which eventually reduces the quality of our eyesight (2).
High levels of A.G.E.s in the circulation is associated with increased risk of cardiovascular disease. A.G.E.s are thought to stick to the walls of blood vessels leading to their blockage and increased risk of heart attack (5).
In the vasculature, A.G.E.s stick to vessels leading to their blockage. They are also found fastened to proteins that are found in the vasculature such as blood cells leading to their dysfunction and disease (14).
A.G.E.s are found in bones, cartilage, muscles, tendons, ligaments, and nerves, where they are associated with osteoporosis, osteoarthritis, sarcopenia, tendinopathy, and neuropathy (11).
In the pancreas, high levels of A.G.E.s lead to degeneration of the beta cells which are critical in controlling pancreatic function and are also involved in pancreatic cancer (6).